Design &
Development
SPECIALIZED SOLUTIONS
Calcium Phosphates
Calcium phosphate ceramics have been used as bone substitutes due to its similarity to the mineral part of the natural bone so that they can be recognized, dissolved and remodeled as new bone tissue. This synthetic bone graft substitutes are highly osteoconductive and bioactive, forming a strong bond to the host bone providing the adequate environment for the remodeling process. Calcium phosphate materials varying with chemistry have different dissolution rates and degradation rates. Generally speaking, dense hydroxyapatite (HA) is non-degradable or slowly degradable, tricalcium phosphate (TCP) is fast degradable or degradable, and biphasic calcium phosphates containing both HA and TCP are in between.
Bioceramed produces the HA and the biphasic mixtures of HA and TCP raw materials, used to incorporate in their products.
Chitosan
Neocement® incorporats in its composition chitosan, a polysaccharide widely used in orthopedic treatment since it was shown to promote osteoblastic cell growth.
The biological properties of chitosan also include good biocompatibility and biodegradability as well as analgesic, hemostatic, antimicrobian and antioxidant properties. These properties come from the presence of amino groups that confers its positive (cationic) nature.
RESEARCH & DEVELOPMENT
We believe that being a company that creates innovation and knowledge contributes not only to the collective success of the company, but also to sustainable growth, economic viability,
the development and well-being of society.
Bioceramed continuously develops new solutions for bone regeneration and has contributed as active partner in several academic projects with several Universities and research institutes.
PROJECTS UNDER DEVELOPMENT
BiOsseoSpine
This project aims to produce an innovative membrane capable of promoting bone regeneration. This membrane will preferably be applied in posterolateral spinal fusion surgery, functioning as a bone bridge in the union of the transverse processes of adjacent vertebrae. The membrane will have inorganic powders in its composition, including calcium phosphates or bioglass.
BioRobotBeads
The BioRobotBeads project has as main objective the development of an innovative robotic system for the synthesis of biomaterials and production of particles (nano, micro, macro). The advantage of this system will be the optimization of the synthesis conditions of selected reagents/materials in order to obtain new and improved biomaterials with properties similar to those of native tissues, namely bone tissue.
GradImp
The main objective of the GradImp project is to develop a new concept of biodegradable iron implants that allow improved mechanical behavior and degradation rate and biocompatibility compared to compact iron. In view of this objective, an advanced fabrication technique, Selective Laser Melting (SLM), will be studied in order to be able to build complex structures with high precision.
TBMED
This project aims to support SMEs that intend to carry out clinical research on medical devices
high-risk innovators. In this case, clinical research on the Neocement® product is being supported.
COMPLETED PROJECTS
CardHeal
The CartHeal project aimed to contribute to the development of a new concept of prostheses
of the hip with greater durability and containing drugs, capable of reducing the need for revisions,
and to facilitate post-operative recovery.
ANTInfect
This project aimed to develop a theranostic system to prevent / treat infections associated with problematic wounds, namely in patients with compromised vascularization (such as diabetic patients) and wounds infected with multi-resistant microorganisms.
NANOSAN
Development of a disinfectant - spray - containing chitosan particles, which allows disinfecting surfaces and providing protection, even after the disinfectant evaporates.
STEREOSTRAT
https://sites.google.com/view/stereostrat/home?authuser=0
The STEReoSTRAT project aimed to study the effect of conventional methods and new sterilization methods on the properties and performance of drug-loaded hydrogels for biomedical applications. It involved the optimization of sterilization procedures, as well as the modification of the hydrogels, in order to increase their resistance to possible harmful effects of sterilization and guarantee an adequate drug release behavior.
SurfLenses
https://surflences.wixsite.com/surflences
The SurfLenses project aimed to develop new efficient systems that allow the release of
drugs at a controlled rate for the treatment / prophylaxis of eye diseases and post-surgical infections.
Various strategies were followed, with particular attention being paid to coating/surface modification of ophthalmic lens materials loaded with drugs for contact lenses and intraocular lenses.
BIOHYBRID
The BIOHYBRID consortium was developed with the general objective of developing an innovative device for the regenerative treatment of peripheral nerve injuries. This consortium was made up of three SMEs, as well as six recognized academic partners in the scientific areas of interest to the project.